期刊
PROGRESS IN RETINAL AND EYE RESEARCH
卷 45, 期 -, 页码 1-29出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.preteyeres.2014.11.005
关键词
Age-related macular degeneration; Choroidmacula; Complement system; Endothelial cells; Choriocapillaris; Pathophysiology
资金
- National Eye Institute [EY-016822, EY-024605]
- National Institutes of Health grant [1DP2OD007483]
- Elmer and Sylvia Sramek Charitable Foundation
- Martin and Ruth Carver Chair in Ocular Cell Biology
Age-related macular degeneration (AMD) is a common and devastating disease that can result in severe visual dysfunction. Over the last decade, great progress has been made in identifying genetic variants that contribute to AMD, many of which lie in genes involved in the complement cascade. In this review we discuss the significance of complement activation in AMD, particularly with respect to the formation of the membrane attack complex in the aging choriocapillaris. We review the clinical, histological and biochemical data that indicate that vascular loss in the choroid occurs very early in the pathogenesis of AMD, and discuss the potential impact of vascular dropout on the retinal pigment epithelium, Bruch's membrane and the photoreceptor cells. Finally, we present a hypothesis for the pathogenesis of early AMD and consider the implications of this model on the development of new therapies. (C) 2014 Elsevier Ltd. All rights reserved.
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