期刊
PROGRESS IN RETINAL AND EYE RESEARCH
卷 45, 期 -, 页码 111-131出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.preteyeres.2014.12.001
关键词
Endoplasmic reticulum stress; Unfolded protein response; Retina; Angiogenesis; VEGF; Endothelial cells
资金
- NIH/NEI [EY019949, EY025061, EY007361]
- Oklahoma Center for the Advancement of Science and Technology [HR10-060]
- American Diabetes Association [7-11-BS-182]
- Research to Prevent Blindness
Angiogenesis is a complex, step-wise process of new vessel formation that is involved in both normal embryonic development as well as postnatal pathological processes, such as cancer, cardiovascular disease, and diabetes. Aberrant blood vessel growth, also known as neovascularization, in the retina and the choroid is a major cause of vision loss in severe eye diseases, such as diabetic retinopathy, age-related macular degeneration, retinopathy of prematurity, and central and branch retinal vein occlusion. Yet, retinal neovascularization is causally and dynamically associated with vasodegeneration, ischemia, and vascular remodeling in retinal tissues. Understanding the mechanisms of retinal neovascularization is an urgent unmet need for developing new treatments for these devastating diseases. Accumulating evidence suggests a vital role for the unfolded protein response (UPR) in regulation of angiogenesis, in part through coordinating the secretion of pro-angiogenic growth factors, such as VEGF, and modulating endothelial cell survival and activity. Herein, we summarize current research in the context of endoplasmic reticulum (ER) stress and UPR signaling in retinal angiogenesis and vascular remodeling, highlighting potential implications of targeting these stress response pathways in the prevention and treatment of retinal vascular diseases that result in visual deficits and blindness. (C) 2014 Elsevier Ltd. All rights reserved.
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