期刊
JOURNAL OF VIROLOGY
卷 88, 期 9, 页码 5195-5199出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.03764-13
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资金
- [NIH U19 AI107810]
- [NIH HHSN272201000019I-HHSN27200003-Task A57]
Human dipeptidyl peptidase 4 (hDPP4) was recently identified as the receptor for Middle East respiratory syndrome coronavirus (MERS-CoV) infection, suggesting that other mammalian DPP4 orthologs may also support infection. We demonstrate that mouse DPP4 cannot support MERS-CoV infection. However, employing mouse DPP4 as a scaffold, we identified two critical amino acids (A288L and T330R) that regulate species specificity in the mouse. This knowledge can support the rational design of a mouse-adapted MERS-CoV for rapid assessment of therapeutics.
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