期刊
JOURNAL OF VIROLOGY
卷 88, 期 23, 页码 13923-13927出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01923-14
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- Delegation Generale de l'Armement (G. Vergnaud, the French Army)
Lassa virus (LASV), which causes a viral hemorrhagic fever, inhibits the innate immune response. The exonuclease (ExoN) domain of its nucleoprotein (NP) is implicated in the suppression of retinoic acid-inducible gene I (RIG-I) signaling. We show here that a LASV in which ExoN function has been abolished strongly activates innate immunity and that this effect is dependent on RIG-I signaling. These results highlight the key role of NP ExoN function in the immune evasion that occurs during LASV infection.
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