期刊
JOURNAL OF VIROLOGY
卷 89, 期 2, 页码 1468-1473出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02293-14
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资金
- National BioResource Project of the Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT)
- MEXT
- Ministry of Health, Labor and Welfare of Japan
- Grants-in-Aid for Scientific Research [24390116] Funding Source: KAKEN
Toll-like receptor 7 and Myd88 are required for antiretroviral antibody and germinal center responses, but whether somatic hypermutation and class-switch recombination are required for antiretroviral immunity has not been examined. Mice deficient in activation-induced cytidine deaminase (AID) resisted Friend virus infection, produced virus-neutralizing antibodies, and controlled viremia. Passive transfer demonstrated that immune IgM from AID-deficient mice contributes to Friend virus control in the presence of virus-specific CD4(+) T cells.
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