期刊
JOURNAL OF VIROLOGY
卷 88, 期 7, 页码 3902-3910出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.03001-13
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资金
- Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX
- National Institutes of Health [R01GM066170, R01GM106218]
The outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infections and diseases represents a potential threat for worldwide spread and requires development of effective therapeutic strategies. In this study, we revealed a novel positive function of an exchange protein directly activated by cyclic AMP 1 (cAMP-1; Epac-1) on MERS-CoV replication. Specifically, we have shown that Epac-specific inhibitor treatment or silencing Epac-1 gene expression rendered cells resistant to viral infection. We believe Epac-1 inhibitors deserve further study as potential therapeutic agents for MERS-CoV infection.
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