期刊
JOURNAL OF VIROLOGY
卷 88, 期 3, 页码 1849-1853出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02907-13
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类别
资金
- NIH [U01 AI070495, U01 AI082100, R01 AI069317, U54 AI065359]
- Fundacao para a Ciencia e a Tecnologia-Ministerio da Educacao e Ciencia (Portugal) [DELIN-HIVERA/0002/2013]
- [SFRH/BPD/72037/2010]
- Fundação para a Ciência e a Tecnologia [SFRH/BPD/72037/2010, HIVERA/0002/2013] Funding Source: FCT
Rigid amphipathic fusion inhibitors (RAFIs) are lipophilic inverted-cone-shaped molecules thought to antagonize the membrane curvature transitions that occur during virus-cell fusion and are broad-spectrum antivirals against enveloped viruses (Broad-SAVE). Here, we show that RAFIs act like membrane-binding photosensitizers: their antiviral effect is dependent on light and the generation of singlet oxygen (O-1(2)), similar to the mechanistic paradigm established for LJ001, a chemically unrelated class of Broad-SAVE. Photosensitization of viral membranes is a common mechanism that underlies these Broad-SAVE.
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