期刊
JOURNAL OF VIROLOGY
卷 87, 期 21, 页码 11912-11915出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01680-13
关键词
-
类别
资金
- Intramural AIDS Targeted Antiviral Program, NIH
- Intramural Research Program of the Center for Cancer Research, NCI
- NCI, NIH [HHSN261200800001E]
- SAIC-Frederick, Inc.
The enrichment of HIV-1 macromolecules at the uropod of polarized T cells can significantly promote virus assembly and cell-mediated infection. Using live-cell fluorescence microscopy, we demonstrate that full-length HIV-1 RNA is enriched at the uropod membrane; furthermore, the presence of HIV-1 Gag containing a functional nucleocapsid domain is necessary for this HIV-1 RNA enrichment. The results from these studies provide novel insights into the mechanism of HIV-1 replication in polarized T cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据