期刊
JOURNAL OF VIROLOGY
卷 87, 期 8, 页码 4778-4782出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.03291-12
关键词
-
类别
资金
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
To date, a laboratory animal model for the study of Sin Nombre virus (SNV) infection or associated disease has not been described. Unlike infection with Andes virus, which causes lethal hantavirus pulmonary syndrome (HPS)-like disease in hamsters, SNV infection is short-lived, with no viremia and little dissemination. Here we investigated the effect of passaging SNV in hamsters. We found that a host-adapted SNV achieves prolonged and disseminated infection in hamsters, including efficient replication in pulmonary endothelial cells, albeit without signs of disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据