期刊
JOURNAL OF VIROLOGY
卷 88, 期 1, 页码 745-751出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02568-13
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资金
- Chinese Ministry of Science and Technology [2012CB911100, 2013ZX0001-005]
- Chinese Ministry of Education [IRT1016]
- Key Laboratory of Molecular Virology, Jilin Province [20102209]
- China Scholarship Council to Wei Wei
MLN4924 is a first-in-class cancer drug that inhibits the Nedd8-activating enzyme (NAE). Herein, we report that MLN4924 inhibits Vpx/Vpr-induced SAMHD1 degradation by inhibiting the neddylation of E3 ubiquitin ligase and blocks macaque simian immunodeficiency virus (SIVmac) replication in myeloid cells. SAMHD1 is required for MLN4924-mediated SIVmac inhibition. Our findings indicate the potential efficacy of inhibiting neddylation as an antiretroviral strategy and identify the readily available anticancer drug MLN4924 as a candidate agent for that purpose.
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