期刊
JOURNAL OF VIROLOGY
卷 87, 期 22, 页码 12496-12498出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02499-13
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- National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services [HHSN266200700005C]
- American Lebanese Syrian Associated Charities (ALSAC)
Recently, novel H7N9 influenza viruses have caused an unprecedented outbreak in humans. Pigs are an important intermediate host for influenza; thus, we assessed the replication ability of three human H7N9 viruses (A/Anhui/1/2013, A/Shanghai/1/2013, A/Shanghai/2/2013) in swine tissue explants. All viruses tested replicated efficiently in explants from tracheas and bronchi, with limited replication in alveolar cells. Swine respiratory tissue explants can serve as an efficient model for screening replication potential of newly emerging H7N9 viruses.
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