期刊
JOURNAL OF VIROLOGY
卷 88, 期 4, 页码 2323-2326出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02521-13
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- Canadian Cancer Society
The Epstein-Barr virus (EBV) EBNA1 protein plays important roles in latent infection, including transcriptional activation of EBV latency genes by binding to the family-of-repeats (FR) element. Through a proteomic approach, we previously identified an interaction between EBNA1 and the histone chaperone nucleophosmin. Here we show that the EBNA1-nucleophosmin interaction is direct and requires the Gly-Arg-rich sequences that contribute to transactivation. Additionally, nucleophosmin is recruited by EBNA1 to the FR element and is required for EBNA1-mediated transcriptional activation.
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