期刊
JOURNAL OF VIROLOGY
卷 87, 期 12, 页码 7160-7165出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00526-13
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资金
- Deutsche Forschungsgemeinschaft
- Hector Foundation
It has been reported that HIV-1 Vpu mediates the degradation of interferon regulatory factor 3 (IRF-3) to avoid innate immune sensing. Here, we show that Vpu does not deplete IRF-3 from transfected cell lines or HIV-1-infected primary cells. Furthermore, the Vpu-dependent suppression of beta interferon expression described in previous studies could be ascribed to inhibition of NF-kappa B activation. Thus, Vpu suppresses innate immune activation through inhibition of NF-kappa B rather than degradation of IRF-3.
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