期刊
JOURNAL OF VIROLOGY
卷 86, 期 23, 页码 13081-13084出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01741-12
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资金
- Fondo de Investigacion Sanitaria (FIS) project from the Instituto de Salud Carlos III [PI09/00278]
Several factors are involved in the control of HIV transcription/replication, including epigenetic modifications at the promoter level. Analysis of the HIV long terminal repeat (LTR) methylation status in infected patients controlling viremia is scarce. Herein, we show a higher degree of DNA methylation in the 5'-LTR of long-term nonprogressor and elite controller (LTNP/EC) versus progressor patients and a positive correlation with time of infection, indicating a certain contribution of HIV LTR silencing in reducing the number of replicating viruses which may account for a delayed progression.
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