期刊
JOURNAL OF VIROLOGY
卷 86, 期 19, 页码 10880-10884出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01162-12
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- NIAID
The respiratory syncytial virus (RSV) G and F glycoproteins are the neutralization antigens, and G also is expressed in a soluble form (sG). Previously, sG was demonstrated to reduce the efficiency of RSV antibody-mediated neutralization by serving as an antigen decoy and to inhibit the antibody-mediated antiviral effects of Fc receptor-bearing leukocytes. The present study demonstrated that effective antibody-mediated restriction in vivo, and the evasion of this restriction by sG, involves pulmonary macrophages and complement, but not neutrophils.
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