期刊
JOURNAL OF VIROLOGY
卷 86, 期 6, 页码 3393-3397出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.06745-11
关键词
-
类别
资金
- Vaccine Research Center, NIAID, NIH
HIV-1 neutralizing monoclonal antibodies (MAbs) define key targets for vaccine development and are being considered for passive prevention of infection. We analyzed the interaction of MAbs to two independent epitopes on the viral envelope glycoprotein. Potently neutralizing MAbs to the CD4 binding site and V1V2 region displayed no in vitro cross-competition and displayed additive, though not synergistic, neutralization activity. Predicted neutralization coverage of a combination of two MAbs reached 97% on a 208-isolate panel.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据