期刊
JOURNAL OF VIROLOGY
卷 86, 期 13, 页码 7444-7447出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00467-12
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- Genentech, Inc./Hoffman-LaRoche, Ltd.
Anti-cytomegalovirus (anti-CMV) hyperimmune globulin (HIG) has demonstrated efficacy in preventing CMV disease in solid-organ transplant patients as well as congenital disease when administered to pregnant women. To identify the neutralizing component of cytomegalovirus hyperimmune globulin (CMV-HIG), we performed serial depletions of CMV-HIG on cell-surface-expressed CMV antigens as well as purified antigens. Using this approach, we demonstrate that the major neutralizing antibody response is directed at the gH/gL/UL128/UL130/UL131 complex, suggesting little role for anti-gB antibodies in CMV-HIG neutralization.
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