期刊
JOURNAL OF VIROLOGY
卷 86, 期 12, 页码 7003-7007出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00411-12
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资金
- ASM Robert D. Watkins Graduate Research Fellowship
- NIH [GM 50740, AI 52341, R21 AI 083952-01]
- NIH NRSA [F32 GM067519]
- Howard Hughes Medical Institute
- Louis Stokes Alliance for Minority Participation Bridge
- NSF [HRD-0602359]
The herpes simplex virus 1 (HSV-1) U(L)21 gene encodes a 62-kDa tegument protein with homologs in the alpha-, beta-, and gammaherpesvirus subfamilies. In the present study, we characterized a novel U(L)21-null virus and its genetic repair to determine whether this protein plays a role in early stages of the HSV-1 replication cycle. Single-step growth analyses, protein synthesis time courses, and mRNA quantifications indicated that the absence of U(L)21 results in a delay early in the HSV-1 replication cycle.
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