期刊
JOURNAL OF VIROLOGY
卷 86, 期 22, 页码 12431-12434出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01514-12
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资金
- National Science Foundation [30530020, 81028011]
- Ministry of Science and Technology of China [2012CB910203, 2011CB504805]
Zinc finger antiviral protein (ZAP) is a host factor that specifically inhibits the replication of certain viruses by binding to specific viral mRNAs and repressing mRNA expression. Here we report that ZAP inhibits expression of murine gammaherpesvirus 68 (MHV-68) M2, which plays important roles in establishment and maintenance of viral latency. Downregulation of endogenous ZAP in cells harboring latent MHV-68 promoted lytic replication of the virus. These results suggest that ZAP inhibits M2 expression and regulates the maintenance of MHV-68 latency.
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