期刊
JOURNAL OF VIROLOGY
卷 85, 期 10, 页码 5220-5223出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00284-11
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类别
资金
- National Institutes of Health [AI45297, AI064074, AI44667, RR025747 CTSA, AI50410]
- Merck
- GlaxoSmithKline
Despite successful antiretroviral therapy (ART), low-level viremia (LLV) may be intermittently detected in most HIV-infected patients. Longitudinal blood plasma and resting CD4(+) T cells were obtained from two patients on suppressive ART to investigate the source of LLV. Single-genome sequencing of HIV-1 env from LLV plasma was performed, and the sequences were compared to sequences recovered from limiting-dilution outgrowth assays of resting CD4(+) T cells. The circulating LLV virus clone was identical to virus recovered from outgrowth assays from pools of millions of resting CD4(+) T cells. Understanding the sources of LLV requires evaluation of all possible reservoirs of persistent HIV infection.
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