期刊
JOURNAL OF VIROLOGY
卷 85, 期 16, 页码 8422-8426出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00452-11
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资金
- NIH (NIAD) Northeast Center of Excellence for Biodefense and Emerging Infectious Disease Research [U54AI057158]
- NIH [R01AI076335, R21NS073781]
We have previously described heterotypic peptides from parainfluenza virus that potently inhibit Nipah virus in vitro but are not efficacious in vivo. In contrast, our second-generation inhibitors, featuring a cholesterol moiety, are also efficacious in vivo. The difference between in vitro and in vivo results led us to investigate the basis for this discrepancy. Here, we compare the activities of the compounds in standard laboratory cells and in cells relevant to the natural tropism of Nipah virus, i.e., primary neurons, and show that while our first-generation inhibitors are poorly active in primary neurons, the cholesterol-conjugated compounds are highly potent. These results highlight the advantage of evaluating antiviral potency in cells relevant to natural host target tissue.
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