期刊
JOURNAL OF VIROLOGY
卷 85, 期 12, 页码 6060-6064出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02033-10
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资金
- NIH [AI43222, DA030156]
- Division of Intramural Research, NIAID, NIH
- American Foundation for AIDS Research
Highly active antiretroviral therapy (HAART) can reduce plasma HIV-1 levels to below the detection limit. However, due to the latent reservoir in resting CD4(+) cells, HAART is not curative. Elimination of this reservoir is critical to curing HIV-1 infection. Agents that reactivate latent HIV-1 through nonspecific T cell activation are toxic. Here we demonstrate in a primary CD4(+) T cell model that the FDA-approved drug disulfiram reactivates latent HIV-1 without global T cell activation. The extent to which disulfiram reactivates latent HIV-1 in patient cells is unclear, but the drug alone or in combination may be useful in future eradication strategies.
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