期刊
JOURNAL OF VIROLOGY
卷 85, 期 8, 页码 4035-4040出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02160-10
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资金
- Ministry of Education, Science, Sports, Culture and Technology, Japan
- Grants-in-Aid for Scientific Research [23590443, 23590909, 22390087] Funding Source: KAKEN
The current study demonstrates that adenovirus virus-associated RNA (VA) is recognized by retinoic acid-inducible gene I (RIG-I), a cytosolic pattern recognition receptor, and activates RIG-I downstream signaling, leading to the induction of type I interferons (IFNs), similarly to Epstein-Barr virus-encoded small RNA. Further analysis revealed that adenovirus infection leads to biphasic type I IFN induction at 12 to 24 h and 48 to 60 h postinfection. The later induction coincided with VA expression and was reduced by virus UV inactivation or RIG-I silencing. These results suggest that VA-mediated RIG-I activation is involved in activating innate immune responses during adenovirus infection.
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