期刊
JOURNAL OF VIROLOGY
卷 85, 期 20, 页码 10905-10908出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00700-11
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资金
- NIH [P01 AI058113, R21 AI085306, HHSN272200900047C]
- DOD [HDTRA1-08-10-BRCWMD-BAA]
The conserved influenza virus hemagglutinin (HA) stem domain elicits cross-reactive antibodies, but epitopes in the globular head typically elicit strain-specific responses because of the hypervariability of this region. We isolated human monoclonal antibody 5J8, which neutralized a broad spectrum of 20th century H1N1 viruses and the 2009 pandemic H1N1 virus. Fine mapping of the interaction unexpectedly revealed a novel epitope between the receptor-binding pocket and the Ca(2) antigenic site on HA. This antibody exposes a new mechanism underlying broad immunity against H1N1 influenza viruses and identifies a conserved epitope that might be incorporated into engineered H1 virus vaccines.
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