期刊
JOURNAL OF VIROLOGY
卷 86, 期 2, 页码 1244-1249出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.06121-11
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资金
- DFG
- MWK
- International Graduate School in Molecular Medicine
Semen is the major vector for HIV-1 transmission. We previously isolated C-proximal fragments of the prostatic acid phosphatase ( PAP) from semen which formed amyloid fibrils that potently enhanced HIV infection. Here, we used the same methodology and identified another amyloidogenic peptide. Surprisingly, this peptide is derived from an N-proximal fragment of PAP (PAP85-120) and forms, similar to the C-proximal fragments, positively charged fibrillar structures that increase virion attachment to cells. Our results provide a first example for amyloid formation by fragments of distinct regions of the same precursor and further emphasize the possible importance of amyloidogenic peptides in HIV transmission.
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