期刊
JOURNAL OF VIROLOGY
卷 85, 期 17, 页码 8884-8893出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00792-11
关键词
-
类别
资金
- NIH Public Health Service [AI 50237]
- NIH [T32 AI07471]
Inhibition of translation is an integral component of the innate antiviral response and is largely accomplished via interferon-activated phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2 alpha). To successfully infect a host, a virus must overcome this blockage by either controlling eIF2 alpha phosphorylation or by utilizing a noncanonical mode of translation initiation. Here we show that enterovirus RNA is sensitive to translation inhibition resulting from eIF2 alpha phosphorylation, but it becomes resistant as infection progresses. Further, we show that the cleavage of initiation factor eIF5B during enteroviral infection, along with the viral internal ribosome entry site, plays a role in mediating viral translation under conditions that are nonpermissive for host cell translation. Together, these results provide a mechanism by which enteroviruses evade the antiviral response and provide insight into a noncanonical mechanism of translation initiation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据