期刊
JOURNAL OF VIROLOGY
卷 85, 期 3, 页码 1396-1399出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01655-10
关键词
-
类别
资金
- NIH/NIAID [NOI-AI-25491]
- Stephen G. and Susan E. Denkers Family Foundation
- USDA CSREES [2005-38420-15813]
- NIH [RO1-NS-040334]
While chronic wasting disease (CWD) prion transmission, entry, and trafficking remain incompletely elucidated, natural exposure of the oral and/or nasal mucous membranes seems certain. Cervids commonly sustain minor lesions on oral mucous membranes that could have an impact on susceptibility to prion infection. To explore this potential cofactor, we studied cohorts of cervid PrP transgenic mice with or without superficial abrasions on the lingual mucosa to determine whether minor oral mucosa lesions may enhance susceptibility to CWD infections. Results demonstrated that minor lingual abrasions substantially facilitate CWD transmission, revealing a cofactor that may be significant in cervids and perhaps other species.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据