期刊
JOURNAL OF VIROLOGY
卷 84, 期 15, 页码 7898-7903出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00885-10
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资金
- NIH [R01 AI057906, R21 AI081957]
- Children's Research Institute
- CNMC Board of Visitors
Human cytomegalovirus (HCMV) UL37 proteins traffic sequentially from the endoplasmic reticulum (ER) to the mitochondria. In transiently transfected cells, UL37 proteins traffic into the mitochondrion-associated membranes (MAM), the site of contact between the ER and mitochondria. In HCMV-infected cells, the predominant UL37 exon 1 protein, pUL37x1, trafficked into the ER, the MAM, and the mitochondria. Surprisingly, a component of the MAM calcium signaling junction complex, cytosolic Grp75, was increasingly enriched in heavy MAM from HCMV-infected cells. These studies show the first documented case of a herpesvirus protein, HCMV pUL37x1, trafficking into the MAM during permissive infection and HCMV-induced alteration of the MAM protein composition.
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