期刊
JOURNAL OF VIROLOGY
卷 85, 期 6, 页码 3015-3019出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01846-10
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资金
- U.S. National Institutes of Health [AI078799]
- Harvard University Center for AIDS Research
- Doris Duke Clinical Scientist Development Award
- Canadian Institutes of Health Research
- Ragon Institute
- Spanish AIDS network [RD06/0006]
- Catalan HIV Vaccine Development Program (HIVACAT)
- Swiss National Science Foundation
- Bill and Melinda Gates Foundation
- Mark and Lisa Schwartz Foundation
- ICREA Funding Source: Custom
Human immunodeficiency virus type 1 (HIV-1) elite controllers maintain undetectable levels of viral replication in the absence of antiretroviral therapy (ART), but their underlying immunological and virological characteristics may vary. Here, we used a whole-genome transcriptional profiling approach to characterize gene expression signatures of CD4 T cells from an unselected cohort of elite controllers. The transcriptional profiles for the majority of elite controllers were similar to those of ART-treated patients but different from those of HIV-1-negative persons. Yet, a smaller proportion of elite controllers showed an alternative gene expression pattern that was indistinguishable from that of HIV-1-negative persons but different from that of highly active antiretroviral therapy (HAART)-treated individuals. Elite controllers with the latter gene expression signature had significantly higher CD4 T cell counts and lower levels of HIV-1-specific CD8(+) T cell responses but did not significantly differ from other elite controllers in terms of HLA class I alleles, HIV-1 viral loads determined by ultrasensitive single-copy PCR assays, or chemokine receptor polymorphisms. Thus, these data identify a specific subgroup of elite controllers whose immunological and gene expression characteristics approximate those of HIV-1-negative persons.
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