期刊
JOURNAL OF VIROLOGY
卷 84, 期 16, 页码 8322-8326出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00633-10
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- National Institute of Neurological Disorders and Stroke [2RO1 NS040334-04]
- National Institute of Allergy and Infectious Diseases [1P01AI077774-01]
- Training Program in Therapeutic Strategies for Neurodegeneration [T32 DA022738]
Cell-based measurement of prion infectivity is currently restricted to experimental strains of mouse-adapted scrapie. Having isolated cell cultures with susceptibility to prions from diseased elk, we describe a modification of the scrapie cell assay allowing evaluation of prions causing chronic wasting disease, a naturally occurring transmissible spongiform encephalopathy. We compare this cervid prion cell assay to bioassays in transgenic mice, the only other existing method for quantification, and show this assay to be a relatively economical and expedient alternative that will likely facilitate studies of this important prion disease.
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