期刊
JOURNAL OF VIROLOGY
卷 83, 期 13, 页码 6917-6921出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00081-09
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类别
资金
- NIH [AI22795]
- NIGMS [58939]
Varicella-zoster virus (VZV) is renowned for its low titers. Yet investigations to explore the low infectivity are hampered by the fact that the VZV particle-to-PFU ratio has never been determined with precision. Herein, we accomplish that task by applying newer imaging technology. More than 300 images were taken of VZV-infected cells on 4 different samples at high magnification. We enumerated the total number of viral particles within 25 cm(2) of the infected monolayer at 415 million. Based on these numbers, the VZV particle:PFU ratio was approximately 40,000:1 for a cell-free inoculum.
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