期刊
JOURNAL OF VIROLOGY
卷 83, 期 16, 页码 8247-8253出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00897-09
关键词
-
类别
资金
- NIH [R21 AI068488-02, R01 AI077376, GM43940]
- Medical Research Council (MRC) UK
- National Center for Research Resources (NCRR) [P51 RR000167, P40 RR019995]
- Research Facilities Improvement Program [RR15459-01, RR020141-01]
- Medical Research Council [G0501963] Funding Source: researchfish
- MRC [G0501963] Funding Source: UKRI
Human and simian immunodeficiency viruses (HIV/SIV) exhibit enormous sequence heterogeneity within each infected host. Here, we use ultradeep pyrosequencing to create a comprehensive picture of CD8(+) T-lymphocyte (CD8-TL) escape in SIV-infected macaques, revealing a previously undetected complex pattern of viral variants. This increased sensitivity enabled the detection of acute CD8-TL escape as early as 17 days postinfection, representing the earliest published example of CD8-TL escape in intrarectally infected macaques. These data demonstrate that pyrosequencing can be used to study the evolution of CD8-TL escape during immunodeficiency virus infection with an unprecedented degree of sensitivity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据