期刊
JOURNAL OF VIROLOGY
卷 83, 期 13, 页码 6947-6951出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00416-09
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资金
- National Institutes of Health (NIAID) [I076335, AI31971]
- Northeast Center of Excellence for Bio-Defense and Emerging Infections Disease Research [U54AI057158]
- Developmental and Innovation Research
- Center of Excellence
- March of Dimes
Peptides derived from conserved heptad repeat (HR) regions of paramyxovirus fusion (F) proteins inhibit viral fusion by interfering with the formation of the fusogenic six-helix bundle structure. Peptide efficacy is affected by the strength of the peptide association with the target virus's complementary HR region. Here, we show that a second basis for peptide efficacy lies in the kinetics of F activation by the homotypic attachment protein: efficient F activation by the attachment protein shortens the period during which antiviral molecules targeting intermediate states of F may act, thereby modulating the effectiveness of inhibitory peptides. These results highlight new issues to be considered in developing strategies for fusion inhibitors.
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