期刊
JOURNAL OF VIROLOGY
卷 83, 期 12, 页码 6306-6311出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00213-09
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资金
- Public Health Service, NIAID [RO1 AI21302, RO1 AI46458]
The essential proteins NS1 and NS2 of minute virus of mice are encoded by mRNAs R1 and R2, respectively. R2 is derived from R1 by excision of a large intron and thus splicing governs the relative ratios of NS1 and NS2. Excision of the large intron utilizes a nonconsensus 5' donor site. We identified a U-rich and A-rich intronic sequence immediately downstream of the nonconsensus 5' donor site that functions as an intronic splicing enhancer (ISE) required for efficient large-intron excision. The ISE binds the cellular RNA-processing proteins TIA-1 and TIAR, which enhance usage of the nonconsensus donor.
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