期刊
JOURNAL OF VIROLOGY
卷 83, 期 13, 页码 6941-6946出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00306-09
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资金
- NIH [R56 AI73185-01A1, R01AI080328]
Elite controllers or suppressors (ES) are human immunodeficiency virus type 1 (HIV-1)-infected patients who control viral replication to < 50 copies/ml without antiretroviral therapy. Downregulation of HLA class I molecules is an important mechanism used by HIV-1 to evade the immune system. In this study, we showed that primary isolates from ES are as effective as isolates obtained from patients with progressive HIV-1 disease at downregulating HLA-A*2 and HLA-B*57 molecules on primary CD4(+) T cells. Thus, a diminished ability of viral isolates from ES to evade HIV-specific immune responses probably does not contribute to the control of viral replication in these patients.
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