期刊
JOURNAL OF VIROLOGY
卷 83, 期 18, 页码 9596-9601出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00784-09
关键词
-
类别
资金
- INSERM
- Biotox program
- French Ministere de la Recherche [04G537]
- Agence National de la Recherche
- National Institute of Health [AI059536]
- Deutsche Forschungsgemeinschaft [SFB 593]
- Delegation francaise Generale pour l'Armement
- Fondation pour la Recherche Medicale [FDT20080913612]
- Region Rhone-Alpes Cluster Infectiologie
Ebolavirus (EBOV) is the etiological agent of a severe hemorrhagic fever with a high mortality rate. The spike glycoprotein (GP) is believed to be one of the major determinants of virus pathogenicity. In this study, we demonstrated the molecular mechanism responsible for the downregulation of surface markers caused by EBOV GP expression. We showed that expression of mature GP on the plasma membrane results in the masking of cellular surface proteins, including major histocompatibility complex class I. Overexpression of GP also results in the masking of certain antigenic epitopes on GP itself, causing an illusory effect of disappearance from the plasma membrane.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据