期刊
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
卷 118, 期 3, 页码 153-160出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbiomolbio.2015.04.001
关键词
DCC; Netrin-1; Axon guidance; Structure; UNC5
资金
- Ministry of Education of China
- National Science Foundation of China (NSFC) [91132718]
- NIH [HL48675]
- Peking-Tsinghua Center for Life Sciences
- short-term EMBO postdoctoral fellowship
DCC (Deleted in Colorectal Cancer) is a single-pass transmembrane protein that belongs to the immunoglobulin superfamily. It was originally identified as a prognostic tumor marker and then subsequently found to be a receptor for netrin-1. DCC plays a key role in axon guidance and also in a number of other important cellular processes. This review describes the current progress of the structural biology of DCC with an emphasis on how DCC is involved in the dual functionality of netrin-1 as a chemo-attractant as well as a repellent in axon guidance, referred to as hi-functionality. A perspective about other DCC ligands and the signaling mechanism of the cytoplasmic tail of DCC is also recapitulated. (C) 2015 Elsevier Ltd. All rights reserved.
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