期刊
JOURNAL OF VIROLOGY
卷 84, 期 5, 页码 2623-2628出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02142-09
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资金
- Abbott Scholars Award
- NIH [RO1-AI51345]
While large DNA viruses are thought to have low mutation rates, only a small fraction of their genomes have been analyzed at the single-nucleotide level. Here, we defined the genetic stability of murine cytomegalovirus (MCMV) by whole-genome sequencing. Independently assembled sequences of three sister plaques showed only two single-base-pair substitutions after in vitro passage. In vivo-passaged MCMV likewise demonstrated low mutation rates, comparable to those after in vitro passage, indicating high genome stability of MCMV at the single-nucleotide level in the absence of obvious selection pressure.
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