期刊
JOURNAL OF VIROLOGY
卷 83, 期 19, 页码 10250-10255出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01038-09
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资金
- NIH [R01 AI052056, R01 AI049120, R24 RR015371]
- National Center for Research Resources (NCRR) [P51 RR000167]
- Research Facilities Improvement Program [RR15459 01, RR020141-01]
To determine the role of amino acid sequences of the hemagglutinin-neuraminidase (HN) cytoplasmic tail in Newcastle disease virus (NDV) replication and pathogenicity, we generated recombinant NDVs with a deletion or point mutation in the N-terminal cytoplasmic tail. The first 2-amino-acid deletion in the cytoplasmic tail did not affect the biological characteristics of NDV. However, a 4-amino-acid deletion and the substitution of alanine for serine at position 6 affected cell fusion, pathogenicity, and colocalization of the HN and M proteins of NDV, indicating that these residues of the HN cytoplasmic tail are critical for its specific incorporation into virions.
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