期刊
JOURNAL OF VIROLOGY
卷 83, 期 12, 页码 6318-6322出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00384-09
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资金
- NIAID
- Bill and Melinda Gates Foundation [38650]
The magnitude and character of adenovirus serotype 5 (Ad5)-specific T cells were determined in volunteers with and without preexisting neutralizing antibodies (NAs) to Ad5 who received replication-defective Ad5 (rAd5)-based human immunodeficiency virus vaccines. There was no correlation between T-cell responses and NAs to Ad5. There was no increase in magnitude or activation state of Ad5-specific CD4(+) T cells at time points where antibodies to Ad5 and T-cell responses to the recombinant gene products could be measured. These data indicate that rAd5-based vaccines containing deletions in the E1, E3, and E4 regions do not induce appreciable expansion of vector-specific CD4(+) T cells.
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