期刊
JOURNAL OF VIROLOGY
卷 82, 期 16, 页码 8215-8223出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02575-07
关键词
-
类别
资金
- NCI NIH HHS [CA06927, P30 CA006927] Funding Source: Medline
- NIAID NIH HHS [U01 AI061441, AI061441, R01 AI026522, AI26522] Funding Source: Medline
The liver-specific microRNA miR-122 has been shown to be required for the replication of hepatitis C virus (HCV) in the hepatoma cell line Huh7. The aim of this study was to test if HCV replication can be modulated by exogenously expressed miR-122 in human embryonic kidney epithelial cells (HEK-293). Our results demonstrate that miR-122 enhances the colony formation efficiency of the HCV replicon and increases the steady-state level of HCV RNA in HEK-293 cells. Therefore, we conclude that although miR-122 is not absolutely required, it greatly enhances HCV replication in nonhepatic cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据