期刊
JOURNAL OF VIROLOGY
卷 83, 期 1, 页码 489-492出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01166-08
关键词
-
类别
资金
- BBSRC, United Kingdom
- BBSRC [BB/D012996/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/D012996/1] Funding Source: researchfish
Kaposi's sarcoma-associated herpesvirus-encoded microRNA (miRNA) MiR-K12-11 was recently shown to be a functional ortholog of miR-155, a miRNA that plays a major role in lymphoid malignancies and the modulation of immune responses. Here we show that miR-M4, encoded by the highly oncogenic Marek's disease virus of chickens, shares common targets with miR-155 and thus is also a functional ortholog of miR-155, the first one identified in an alphaherpesvirus. The observation that two distinct oncogenic herpesviruses associated with distinct types of lymphomas in different species encode functional miR-155 orthologs suggested the importance of this miRNA in regulatory pathways and the biology of lymphomagenesis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据