期刊
JOURNAL OF VIROLOGY
卷 82, 期 16, 页码 8224-8229出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02584-07
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资金
- NIAID NIH HHS [T32 AI007536, P01 AI062885, N01 AI030039] Funding Source: Medline
Human metapneumovirus, a leading cause of respiratory tract infections in infants, encodes a small hydrophobic (SH) protein of unknown function. In this study, we showed that infection of airway epithelial cells or mice with recombinant human metapneumovirus lacking SH expression (rhMPV-Delta SH) enhanced secretion of proinflammatory mediators, including interleukin 6 (IL-6) and IL-8, encoded by two NF-kappa B-dependent genes, compared to infection with wild-type rhMPV. RhMPV-Delta SH infection resulted in enhanced NF-kappa B-dependent gene transcription and in increased levels of phosphorylated and acetylated NF-kB without affecting its nuclear translocation, identifying a possible novel mechanism by which paramyxovirus SH proteins modulate NF-kB activation.
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