期刊
JOURNAL OF VIROLOGY
卷 82, 期 9, 页码 4665-4670出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02403-07
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- Howard Hughes Medical Institute Funding Source: Medline
- NCI NIH HHS [R37-CA30488, R37 CA030488] Funding Source: Medline
We recently identified the cytoskeletal regulatory protein moesin as a novel gene that inhibits retroviral replication prior to reverse transcription by downregulation of stable microtubule formation. Here, we provide evidence that overexpression of ezrin, another closely related ezrin-radixin-moesin (ERM) family member, also blocks replication of both murine leukemia viruses and human immunodeficiency virus type 1 (HIV-1) in Rat2 fibroblasts before reverse transcription, while knockdown of endogenous ezrin increases the susceptibility of human cells to HIV-1 infection. Together, these results suggest that ERM proteins may be important determinants of retrovirus susceptibility through negative regulation of stable microtubule networks.
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