期刊
JOURNAL OF VIROLOGY
卷 82, 期 7, 页码 3803-3808出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02532-07
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- NIAID NIH HHS [R01 AI046458, R01 AI056310, R01 AI56310, R01 AI46458] Funding Source: Medline
Degradation of de novo-generated adeno-associated virus type 5 (AAV5) Rep52 and capsid proteins is part of the limited target specificity displayed by adenovirus type 5 E4Orf6-E1B-55k as part of a cullin 5-containing E3 ligase complex. Both Rep and capsid proteins can be found in the ligase complex, and their presence is dependent on interaction between E4Orf6 and elongins B and C. Degradation of AAV5 proteins can be inhibited by a dominant-negative ubiquitin that prevents chain elongation or by small interfering RNA directed against cullin 5.
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