期刊
JOURNAL OF VIROLOGY
卷 82, 期 23, 页码 11976-11978出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01028-08
关键词
-
类别
资金
- South Korean government MOEHRD, Basic Research Promotion Fund [KRF-2007-412-J00304]
- Korea Science and Engineering Foundation [R13-2008-023]
- Korea Basic Science Institute [T28032]
Coxsackievirus is the most important cause of meningitis and encephalitis in infants; an infection is sometimes fatal or may lead to neurodevelopmental defects. Here, we show that coxsackievirus B4 (CVB4) induces an autophagy pathway for replication in rat primary neurons. Notably, calpain inhibitors reduce autophagosome formation. Conversely, the inhibition of the autophagy pathway with 3-methyladenine inhibits calpain activation. This work reveals, for the first time, that calpain is essential for the autophagy pathway and viral replication in CVB4-infected neurons.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据