期刊
JOURNAL OF VIROLOGY
卷 82, 期 17, 页码 8922-8926出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00493-08
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资金
- NSFC [30470076, 30630002, 30670078]
- MOST
- KNAW [2004CB720404]
- [2003CB114202]
The envelope fusion protein F of Plutella xylostella granulovirus is a computational analogue of the GP64 envelope fusion protein of Autographa californica nucleopolyhedrovirus (AcMNPV). Granulovirus (GV) F proteins were thought to be unable to functionally replace GP64 in the AcMNPV pseudotyping system. In the present study the F protein of Agrotis segetum GV (AgseGV) was identified experimentally as the first functional GP64 analogue from GVs. AgseF can rescue virion propagation and infectivity of gp64-null AcMNPV. The AgseF-pseudotyped AcMNPV also induced syncytium formation as a consequence of low-pH-induced membrane fusion.
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