期刊
JOURNAL OF VIROLOGY
卷 82, 期 17, 页码 8900-8905出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00196-08
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资金
- German Research Foundation [SCHM1702/1-1, S1713466, A12, SCHM1702/2-1]
- Akademie der Wissenschaften und Literatur zu Mainz
- German Competence Network for HIV/AIDS
- Wilhelm Sander Foundation
- NTH [IROIAI067057-01A2, 40880]
- UMass Center for AIDS Research [P30 AI-42845]
- graduate college GRK [1071]
- [NTH HL-42257]
- MRC [MC_U117531986] Funding Source: UKRI
- Medical Research Council [MC_U117531986] Funding Source: researchfish
Plasmacytoid dendritic cells (PDC) are major producers of type I interferons (IFN) in response to human immunodeficiency virus type I (HIV-1) infection. To better define the underlying mechanisms, we studied the magnitude of alpha IFN (IFN-alpha) induction by recombinant viruses containing changes in the Env protein that impair or disrupt CD4 binding or expressing primary env alleles with differential coreceptor tropism. We found that the CD4 binding affinity but not the viral coreceptor usage is critical for the attachment of autofluorescing HIV-1 to PDC and for subsequent IFN-alpha induction. Our results illustrate the importance of the gp120-CD4 interaction in determining HIV-1-induced immune stimulation via IFN-alpha production.
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