期刊
JOURNAL OF VIROLOGICAL METHODS
卷 182, 期 1-2, 页码 43-49出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jviromet.2012.03.004
关键词
Influenza virus; Microneutralization test; Immunization; Antibody response; Neutralizing antibody
资金
- Taiwan Center for Disease Control
- National Health Research Institutes
- National Science Council [NSC 100-2321-B-002-013]
Evaluation of the efficacy of influenza vaccines is essential for vaccine development. This study evaluated the neutralizing and hemagglutination-inhibition antibody response in subjects receiving the 2006-07 and 2007-08 seasonal influenza vaccines. ELISA-based microneutralization demonstrated a greater mean-fold increase and seroconversion rate than the hemagglutination-inhibition assay. The increase in the antibody titers against influenza Hi were higher than those against influenza H3 and influenza B, indicating that the H1 vaccine strain in the 2006-07 and 2007-08 seasons was more immunogenic. These data suggest that the neutralizing antibody response is a better measurement of influenza vaccine efficacy. (C) 2012 Elsevier B.V. All rights reserved.
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