期刊
JOURNAL OF VIROLOGICAL METHODS
卷 164, 期 1-2, 页码 88-95出版社
ELSEVIER
DOI: 10.1016/j.jviromet.2009.12.004
关键词
Influenza virus transmission; Mathematical model; Virus viability; Water activity; Airborne virus
资金
- CDC-NIOSH [1 R01 OH009037-01]
- NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH [R01OH009037] Funding Source: NIH RePORTER
A mathematical model was developed to predict the viability of airborne viruses. The model uses water activity as the primary independent variable and an exponential decay function for the viability of the virus. This model was tested using published experimental data obtained by different investigators for influenza. Langat and polio viruses. The aerosolized media were modelled as a binary solution of water and sodium chloride. The water activity is related directly to the solute concentration in the binary solution. The minimum viability usually occurred just above the efflorescence point, which is the relative humidity at which the solution crystallizes. The relationship between water activity and relative humidity is based on the Kohler theory, whereby the Kelvin term was taken into account. Physical explanations are provided on the variation of viral viability at different relative humidity levels. The predictions obtained by the proposed mathematical model compare well with most of the published experimental data. (C) 2009 Elsevier B.V. All rights reserved.
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